Being mostly a mac guy, it pains me to say that because I use a PC at work, I work on a PC more than a Mac. That being said, I have to make these 40 hours a week as productive and as painless as possible. One of my coworkers had told me about Launchy, a tool that gives you a Spotlight/Quicksilver experience on a PC.
This tool has exponentially increased my productivity. No more Start Menu, Quick Launch, or messy desktops. A simple alt+space bar will pull up Launchy and you can type any program, document or folder.
PC or Mac, I really suggest some sort of application launcher. If you are on the Mac, check out spotlight. It’s already installed. Just press command+space bar to activate.